Preferred term
mitochondrial DNA
Is replaced by
Definition
- [Nicole Hance] Mitochondrial DNA (mtDNA) polymerase gamma (Polg) is a heterodimeric enzyme containing a Pol I-like\ catalytic core (PolgA) and an accessory subunit. Mutations in POLGA, affecting the stability of\ mtDNA, have been identified in several human pathologies such as progressive external\ ophthalmoplegia and Alpers' syndrome. Extensive literature shows mitochondrial toxicity\ effects nucleoside analogue reverse transcriptase inhibitors used in the treatment of HIV and\ chronic hepatitis B as a consequence of an inhibitory effect on Polg... , "[Henderson's] the small DNA genome contained in a mitochondrion. \ , "[Montserrat Sánchez-Céspedes] Mitochondrial DNA (mtDNA) is a circular molecule containing 27 genes involved in mitochondrial\ biology and the mitochondrial energy-generating pathway, oxidative phosphorylation (OXPHOS).\ Alterations in mtDNA have been reported to accumulate with age and some mtDNA mutations are known to\ be responsible for specific degenerative diseases. Recently, somatic mtDNA variations have been\ described in human tumors, although their functional implications in tumorigenesis have so far not\ been elucidated...
Broader concept
Entry terms
- mitochondrial DNAs
URI
http://vocabs.lter-europe.net/EnvThes/msa0671